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激光散斑血流成像系统

RFLSI Ⅲ 激光散斑血流成像系统

RFLSI Ⅲ激光散斑血流成像系统基于LSCI(laser speckle contrast imaging)技术设计,具有非侵入性、高帧率、高分辨率的优势,用于实时监测和记录暴露组织器官的血流灌注情况。精准量化微循环血流量,满足广泛的科研场景。
广泛应用于临床前和临床研究,在脑损伤、中风和血管功能、认知障碍研究中,RFLSI III 激光散斑血流成像系已助力发表多篇高分文献。

产品特点

技术参数

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  • 产品特点

1-可靠稳定的数据监测  。
2-全幅高清图像和视频采集,实验数据更直观。  
3-最高每秒120帧采样速率, 实时捕捉动态变化。 
4-内置多种算法,高清与防抖动兼得,各器官研究都适用。
5-友好的分析软件,可授权多台PC进行数据分析。

客户评价

“依赖于高采样率和数据传输速度,设备能具有很快的响应速度,对于样本的刺激造成的血流数据改变能实时反馈。样本数量比价多,因此我们不希望在数据采集上浪费太多时间,瑞沃德激光散斑操作非常简单,数秒钟就能完成拍摄取样。”
——马寅仲 博士
脑血管病生物学与疾病研究室
中国科学院先进技术研究院


“I couldn’t suggest further hardware features as I feel everything the user would need is there. The quality of the images is wonderful,The pixel resolution of the images is very impressive also. 
The user friendly software allows the user to control all aspects of both the operation of the machine but also the analysis of the results. The features available for data analysis, such as the ROI function and blood perfusion graph, allow for exciting results. .....”

——Dr. Samuel M Flaherty
National Graphene Institute 
The University of Manchester


“传统的切片及神经评分不能满足MCAO 模型活体的观测需求,神经症状类似但实际梗死情况有偏差。通过激光散斑血流成像系统能大幅提高成功率,相对于双光子,能够实现大范围全脑血流数据采集。”
——贾洁敏 博士
西湖大学生命科学学院


“The picture is very clear.We can use the Laser Speckle Imagin
System to observe the 5th branch of Mesentery.”

——Yi-Je (Jay) Chen, Ph. D.
Assistant Professor, UC Davis

参考文献

[1] Chen J , Wang L , Xu H , et al. Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage[J]. Nature Communications, 2020, 11(1).

[2] Long C , Liu M , Tian H , et al. Potential Role of Platelet-Activating C-Type Lectin-Like Proteins in Viper Envenomation Induced Thrombotic Microangiopathy Symptom[J]. Toxins, 2020, 12(12):749.

[3] R Li, Shen Y , Li X , et al. Activation of the XBP1s/O-GlcNAcylation Pathway Improves Functional Outcome after Cardiac Arrest and Resuscitation in Young and Aged Mice[J]. Shock, 2021, publish ahead of print.

[4] Shen C , Liu M , Xu R , et al. The 14-3-3ζ–c-Src–integrin-β3 complex is vital for platelet activation[J]. Blood, 2020.

[5] Yu J , Liu Q , Li X , et al. Oxymatrine Improves the Integrity of the Blood-Brain Barrier after Cerebral Ischemia-Reperfusion Injury through the Caveolin-1/MMP-9 Signaling Pathway. 2020.

[6] Wang S , Lv W , Zhang H , et al. Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats[J]. GeroScience, 2020.

[7] Guo Y Z , Ma Y M , Zhang X P , et al. Region-specific changes in aquaporin 4 induced by hyperglycemia underlie the differences in cell swelling in the cortex and striatum after cerebral ischemia-reperfusion[J]. Neuroscience Letters, 754.

[8]Jiao, Yue, Xin-Shang, et al. Activation of G-Protein-Coupled Receptor 30 Protects Neurons against Excitotoxicity through Inhibiting Excessive Autophagy Induced by Glutamate.[J]. ACS chemical neuroscience, 2019, 10(10):4227-4236.

[9] Guo X , Tian Y , Yang Y , et al. Pituitary Adenylate Cyclase-Activating Polypeptide Protects Against Cognitive Impairment Caused by Chronic Cerebral Hypoperfusion[J]. Molecular Neurobiology, 2021:1-14.

[10] Xu K , Gao X , Xia G , et al. Rapid gut dysbiosis induced by stroke exacerbates brain infarction in turn[J]. Gut, 2021, 70(8):gutjnl-2020-323263.

[11] X Zhu, Chen Y , X Xu, et al. SP6616 as a Kv2.1 inhibitor efficiently ameliorates peripheral neuropathy in diabetic mice[J]. EBioMedicine, 2020, 61:103061.

[12] Xu X , Wang W , Wang Z , et al. DW14006 as a Direct AMPKα Activator Ameliorates Diabetic Peripheral Neuropathy in Mice[J]. Diabetes, 2020, 69(9):db191084.

[13] Wu Y , Zeng J , Pluimer B , et al. Microvascular Injury in Mild Traumatic Brain Injury Accelerates Alzheimer-like Pathogenesis in Mice. 2020.

[14] Ma Q , Liu D , Gong R , et al. Mechanically Induced Vasospasm〦valuation of Spasmolytic Efficacy of 10 Pharmaceutical Agents Using Laser Speckle Contrast Imaging[J]. Lasers in Surgery and Medicine, 2020(5).

[15] Cong R , Sun L , Yang J , et al. Protein O-GlcNAcylation alleviates small intestinal injury induced by ischemia-reperfusion and oxygen-glucose deprivation[J]. Biomedicine & Pharmacotherapy, 2021, 138(5):111477.

[16] Fang F , Liu M , Xiao J , et al. Arterial Supercharging Is More Beneficial to Flap Survival Due to Quadruple Dilation of Venules[J]. Journal of Surgical Research, 2019, 247.

[17] Xu B , Xu J , Cai N , et al. Roflumilast prevents ischemic stroke-induced neuronal damage by restricting GSK3β-mediated oxidative stress and IRE1α/TRAF2/JNK pathway[J]. Free Radical Biology and Medicine, 2020, 163.

[18]Wang W, Li R, Miao W, Evans C, Lu L, Lyu J, Li X, Warner DS, Zhong X, Hoffmann U, Sheng H, Yang W. Development and Evaluation of a Novel Mouse Model of Asphyxial Cardiac Arrest Revealed Severely Impaired Lymphopoiesis After Resuscitation. J Am Heart Assoc. 2021 Jun;10(11):e019142. doi: 10.1161/JAHA.120.019142. Epub 2021 May 20. PMID: 34013738; PMCID: PMC8483518.

[19]Zaidi SK, Ahmed F, Alkhatabi H, Hoda MN, Al-Qahtani M. Nebulization of Low-Dose S-Nitrosoglutathione in Diabetic Stroke Enhances Benefits of Reperfusion and Prevents Post-Thrombolysis Hemorrhage. Biomolecules. 2021 Oct 27;11(11):1587. doi: 10.3390/biom11111587. PMID: 34827584; PMCID: PMC8615482.

[20]Li H, Yang Z, Tang Q, Shi Z, Mao Y. Embolic Stroke Model with Magnetic Nanoparticles. ACS Appl Mater Interfaces. 2021 Sep 22;13(37):43993-44001. doi: 10.1021/acsami.1c11377. Epub 2021 Sep 8. PMID: 34495626.

[21]Yang Y, Tian Y, Guo X, Li S, Wang W, Shi J. Ischemia Injury induces mPTP opening by reducing Sirt3. Neuroscience. 2021 Aug 1;468:68-74. doi: 10.1016/j.neuroscience.2021.06.003. Epub 2021 Jun 11. PMID: 34119577.

[22]Tian, Liu, Li, et al. Snake C-Type Lectins Potentially Contribute to the Prey Immobilization in Protobothrops mucrosquamatus and Trimeresurus stejnegeri Venoms[J]. Toxins, 2020, 12(2):105.

 



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