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Rotarod 转棒仪

Rotarod转棒仪常用于药效测试、脑部损伤和运动协调以及抗疲劳相关的疾病研究领域,是一种简单且高效的实验方法。

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技术参数

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Panlab全新系列的转棒仪,更加易用,全新彩色触摸屏幕以及图形化的用户界面,更加形象化地显示每个通道的时间和转速,也使得用户可以通过点击屏幕来轻松地设置运行模式、调节速度和创建实验流程。

用户通过触控屏幕面板来设置相关实验参数,内置高级微处理器可实现精准定时和超精确的速度调节。转棒速度可调节(4-40rmp),可自定义变速时间(30s-10min,1s增量)。实验获得的结果数据实时保存于设备内存中。

操作时,动物被放置于正在旋转的转棒上,同时开始计时器启动,开始计时。当动物从转棒上掉落到对应的通道时,掉落潜伏期(分钟或秒)和掉落时的转棒转速会被记录下来。通道之间具有隔离板,可避免相邻通道的动物运动时相互干扰。

参考文献(部分)

  •  Burberry A, Wells M F, Limone F, et al. C9orf72 suppresses systemic and neural inflammation induced by gut bacteria[J]. Nature, 2020: 1-6.

  • Blacher E, Bashiardes S, Shapiro H, et al. Potential roles of gut microbiome and metabolites in modulating ALS in mice[J]. Nature, 2019, 572(7770): 474-480.

  •  Hoch N C, Hanzlikova H, Rulten S L, et al. XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia[J]. Nature, 2017, 541(7635): 87-91.

  •  Ono K, Keller J, Ramírez O L, et al. Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations[J]. Nature communications, 2020, 11.

  •  Nóbrega-Pereira S, Fernandez-Marcos P J, Brioche T, et al. G6PD protects from oxidative damage and improves healthspan in mice[J]. Nature communications, 2016, 7(1): 1-9.

  • Graber TG et al. Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia. Exp Gerontol. 2018 Jun;106:88-100.

  •  Pak M E, Ahn S M, Jung D H, et al. Electroacupuncture therapy ameliorates motor dysfunction via brain-derived neurotrophic factor and glial cell line-derived  neurotrophic factor in a mouse model of Parkinson’s disease[J]. The Journals of Gerontology: Series A, 2020, 75(4): 712-721.

  • Shimokawa N, Yousefi B, Morioka S, et al. Altered cerebellum development and dopamine distribution in a rat genetic model with congenital hypothyroidism[J]. Journal of neuroendocrinology, 2014, 26(3): 164-175.

  •  Díaz D at al. Bone marrow transplantation improves motor activity in a mouse model of ataxia. J Tissue Eng Regen Med. 2018 Apr;12(4):e1950-e1961.

  • Kossatz E et al. Octadecylpropyl Sulfamide Reduces Neurodegeneration and Restores the Memory Deficits Induced by Hypoxia-Ischemia in Mice. Front Pharmacol. 2018 Apr 19;9:376.   

  • Leitão RA et al. Aquaporin-4 as a New Target against Methamphetamine-Induced Brain Alterations: Focus on the Neurogliovascular Unit and Motivational Behavior. Mol Neurobiol. 2018 Mar;55(3):2056-2069.

  • Niemir N et al. Intravenous administration of scAAV9-Hexb normalizes lifespan and prevents pathology in Sandhoff disease mice. Hum Mol Genet. 2018 Mar 15;27(6):954-968.

  • Sarubbo F et al.Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats. J Neuroimmune Pharmacol. 2018 Mar;13(1):24-38. 

  • Xiong LL et al. Neural Stem Cell Transplantation Promotes Functional Recovery from Traumatic Brain Injury via Brain Derived Neurotrophic Factor-Mediated Neuroplasticity. Mol Neurobiol. 2018 Mar;55(3):2696-2711. 

  •  Pak ME et al. Combined therapy involving electroacupuncture and treadmill exercise attenuates demyelination in the corpus callosum by stimulating oligodendrogenesis in a rat model of neonatal hypoxia-ischemia. Exp Neurol. 2018 Feb;300:222-231. 


长-恢复的.jpg

长-恢复的.jpg

1.全新的触摸屏幕操作界面

2.提供整合大鼠/小鼠版本的设备

3.可靠的机械式方式检测动物掉落

4.各通道独立计时

5.定速模式和匀变速模式    

6.动物掉落潜伏期

7.动物掉落时转棒转速


型号

品名/描述

LE8205

转棒仪-5 只小鼠

LE8305

转棒仪-4 只大鼠

LE8505

转棒仪-4 只大鼠/4 只小鼠


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